Case Report

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CellMed 2024; 14(4): 3.1-3.4

Published online March 29, 2024

https://doi.org/10.5667/CellMed.spc.073

© Cellmed Orthocellular Medicine and Pharmaceutical Association

세포교정영양요법(OCNT)을 이용한 신체의 항상성 개선 사례 연구

홍은아 약사

부산진구 가야대로 745 홍약국

A Case Study on Improving Body Homeostasis Using Ortho-cellular Nutrition Therapy (OCNT)

Pharmacist, Eunah Hong

Hong Pharmacy, 745, Gaya-daero, Busanjin-gu, Busan, 47258, Republic of Korea

Correspondence to : Eunah Hong
E-mail: eunah0720@naver.com

☨ This report has been translated and edited by the CellMed editor-in-chief, Prof. Beom-Jin Lee.

Received: March 29, 2024; Revised: March 29, 2024; Accepted: March 29, 2024

This is an open access article under the CC BY-NC license. (http://creativecommons.org/licenses/by-nc/3.0/)

Objective Case: study on improving body homeostasis by ortho-cellular nutrition therapy.
Methods: A 48-year-old Korean man underwent OCNT due to symptoms of insomnia and decreased physical function due to extreme chronic stress.
Results: After exposure to OCNT, fatigue, sleep quality, and brain fog symptoms improved, and overall physical performance improved, including liver function recovery.
Conclusion: For people who suffer from symptoms of decreased physical function in various aspects due to extreme stress, applying OCNT can help alleviate symptoms.

Keywords Ortho-Cellular Nutrition Therapy (OCNT), Homeostasis, Stress, Chronic Stress

'Stress' is a term in physics, meaning "physical force applied to an object." When applied to medicine, it means "physical and mental stimulation" that burdens an individual or the "reaction" the living body shows when such stimulation is applied.

The human body has a function called homeostasis, which always tries to maintain a certain balance. Homeostasis is a fundamental concept in life phenomena, and one of the critical definitions of disease occurrence is “a breakdown in homeostasis and a decrease in immunity.”

This homeostasis becomes distorted when a robust stressor (a factor that causes stress) is received from the outside or inside. To protect the body from such distortions, restore it, and maintain balance, the body secretes various hormones from the autonomic, nervous, and endocrine systems. In general, it is known that hormones secreted by the autonomic nervous system play an essential role in acute stress, and hormones secreted by the neuroendocrine system play an important role in chronic stress.

When exposed to stress for an extended period, information about stress is transmitted to the hypothalamus through several pathways. Then, the 'corticotropin-releasing factor' is released from the hypothalamus, which stimulates the pituitary gland to secrete adrenocorticotropic hormone. In this case, cortisol, called the 'stress hormone,' is secreted, which increases blood sugar levels and supplies the energy needed to deal with stress. When stress becomes chronic, the secretion of cortisol continues chronically, and if you do not take active measures to maintain homeostasis, the body's balance may be disrupted, and various problems may occur.

The patient, in this case, also suffered from decreased body homeostasis due to excessive chronic stress. As a result, danger signals appeared in various areas, such as insomnia, nosebleeds, arteriosclerosis, obesity, etc. After applying OCTN for a month, fatigue improved, and nosebleeds symptoms were alleviated, but after discontinuation, the same symptoms appeared again, so a second OCTN was performed with additional medication, and we would like to report the progress.

1. Subject

One case of a patient with decreased body homeostasis due to chronic stress was studied.

1) Name: Kim ㅇㅇ (M/48 years old)

2) Diagnosis: fatty liver, hyperlipidemia (suspected ischemic heart disease and arteriosclerosis), obesity

3) Date of onset: November 2022

4) Treatment period: September 2023 to present

5) Main symptoms: chronic fatigue, chronic insomnia, intermittent headaches, abdominal pain that makes it difficult to fall asleep, jaundice due to fatty liver and hyperlipidemia, severe nosebleeds

6) Past history: Insomnia, depression, panic disorder, nosebleeds around 2012

7) Social history: Smoking (a pack a day), drinking (a can of beer a day)

8) Family history: None

9) Current medical history and medications taken: Sleeping pills and prescription medications for panic disorder (Alprazolam 0.25 mg, 1 Remeron TAB 1 mg, Remixil Oddity 30 mg TAB 1 tablet)

2. Method

A) Oral medication

<August 20023>

Notoplex GRN (101, twice a day, 1 packet each time)

OCNT was carried on for one month as shown above.

<November 20023>

Cyaplex-F CAP (303, twice a day, 3 packets each time)

Eufaplex CAP (303, twice a day, 3 packets each time)

Viva Kan CAP (101, twice a day, 1 packet each time)

Notoplex GRN (100, once a day, 1 packet each time)

OCNT was carried on for one month as shown above.

<Present>

Cyaplex-F CAP (300, twice a day, 3 capsules each time)

Eufaplex CAP (300, twice a day, 3 capsules each time)

Viva Kan CAP (100, once a day, 1 capsule each time)

Diverol CAP (100, once a day, 1 capsule each time)

B) Lifestyle

In lifestyle, it was recommended to refrain from late-night snacking and to always have a positive mind. The patient was advised to abstain from alcohol and smoking but has not been successful in adhering to these recommendations.

The subject of this case is a 48-year-old man who has had insomnia for a long time due to extreme stress from family and work life and has been taking sleeping pills and medication for panic disorder since about ten years ago. He had not been able to take good care of his health for a long time due to mental stress. At the company's health checkup in November 2022, he was diagnosed with ischemic heart disease, peripheral vascular disease such as arteriosclerosis, and adult disease due to high LDL cholesterol levels. He was also diagnosed with moderate fatty liver disease. After a health checkup, he was prescribed the drug atorvastatin, which can reduce cholesterol levels, by the hospital. Still, he did not take it and did not actively manage the suspected disease or obesity.

As fatigue worsened around August 2023, severe nosebleeds became one of the physical symptoms, which led to the start of OCTN. After taking Notoplex for a month, fatigue improved, and nosebleeds stopped, but when the symptoms were partially alleviated, the case subject stopped taking the drug. Then, the same symptoms appeared again in November, so OCTN was performed a second time.

In the second OCTN, four products, Cyaplex-F, Eufaplex, Viva Kan, and Notoplex, were taken according to the prescribed dosage and the patient's health condition improved overall body homeostasis. After a month, fatigue was significantly reduced, sleep quality improved, and the number of times neuropsychiatric medication was taken decreased.

As a result, the brain fog phenomenon was significantly improved compared to before the implementation of OCTN, and awareness became clearer. In addition, by combining OCTN with a diet prohibiting late-night snacking, he lost about 4 kg in one month. His abdominal pain, which was so severe that he could not sleep, was reduced to level 1, and his jaundice levels due to fatty liver and hyperlipidemia were also significantly improved (Table 1).

Table 1 . The degree of symptoms perceived by the patient and measurement values during OCNT

Symptoms1st 2023.05.302nd 2023.07.053rd 2023.09.25 (After 1st OCTN)4th 2023.12.31 (After 2nd OCTN)Note
Abdominal pain5421The closer the number is to 1, the less pain there is to the point of being unable to sleep.
Weight71.5 kg72 kg69 kg65 kg-
Jaundice14 mg/dL10 mg/dL4 mg/dL2.3 mg/dLNormal range 0.2~1.2 mg/dL


Since the jaundice level is not yet within the normal range, OCNT is still in progress.

Stress stimulates the nervous system to secrete the stress hormone cortisol, and when stress becomes chronic, the secretion of cortisol continues chronically, disrupting the body's balance. Suppose you do not promptly take an active response to eliminate stress or an indirect response such as exercise or meditation.

In that case, it becomes difficult for the body to maintain homeostasis, ultimately leading to disease development.1,2 It is known that the nervous system is closely related to the immune system. There are reports that chronic psychological stress increases the level of cortisol and suppresses the activity of immune cells, increasing the risk of developing various infectious diseases or cancer.3

Typical diseases known to be related to stress are introduced as follows:

First, excessive secretion of cortisol promotes fat secretion into the blood, and when this increased fat attaches to the coronary artery wall, it causes coronary artery disease.4,5

Second, if excessive chronic stress continuously stimulates the sympathetic nervous system, leading to an increased risk of hypertension and atherosclerosis.6,7

Third, if stress becomes chronic, this state of activation continues, and if it becomes excessive, it can cause depression. 8,9

Fourth, insomnia occurs when the brain becomes overly tense due to environmental changes or stressors.10,11

Diseases caused by stress not only cause discomfort in daily life but can also directly lead to health issues, making appropriate management crucial. If it's difficult to eliminate the stressor itself, methods to restore the body's homeostasis can also be helpful.

Notoplex, which the patient in this case first took due to excessive nosebleeds, has Panax notoginseng as its main ingredient and is known to be effective in treating blood-related diseases. The main effects include hemostasis to stop bleeding, acid blood to disperse stagnant blood, swelling to clear tumors and swollen wounds, and orthodox to relieve pain. Therefore, taking Panax notoginseng extract can improve the patient's microvascular circulation, assist in vascular relaxation, and help alleviate the patient's nasal congestion symptoms.12,13

Anthocyanins are representative antioxidant substances known to improve immune function through various studies,14,15 and there are reports that fucoidan also enhances immune cells.16 The zinc and selenium contained in the product can also help restore a normal immune system, including detoxification of oxidized cells.17,18

In addition, quercetin contained in aronia is a flavonoid compound with antioxidant and anti-inflammatory effects and increases the expression of brain-derived neurotrophic factors in animal model studies and clinical studies. It has also been shown to improve symptoms of depression by helping to increase levels of neurotransmitters such as serotonin and dopamine.19,20

Omega 3, the main ingredient of Eufaplex, is a non-oxidized essential fatty acid known to help produce prostaglandins 1, 2, and 3, eliminating inflammation and helping kill blood clots and cancer cells. In addition, it is known to help the inflammation control system function normally as it is a parent fatty acid that is a raw material for adrenocortical hormones, cell membrane regeneration, vitamin D synthesis, steroid hormones, and bile. In particular, omega-3 effectively reduces triglyceride and cholesterol levels in many studies.21-23

Omega 3 is also a component of brain cell membranes, plays a vital role in brain cell signaling and neurotransmitter production, and can help improve the function of mood-boosting neurotransmitters such as serotonin and dopamine. It has also been reported that it can help improve symptoms of depression by increasing the expression of BDNF (brain-derived neurotrophic factor) and reducing inflammatory mediators, alleviating cranial nerve inflammation.24

The main ingredient in Viva Kan is silymarin, a mixture of flavonoid compounds extracted from the seeds of a plant called milk thistle. The main components are silybin, silicristine, and silidanin, and research results have reported that it can help improve fatty liver through antioxidant and anti-inflammatory effects. As a result of analyzing 17 randomized controlled studies, when silymarin was consumed, liver enzyme levels, AST (GOT), decreased by approximately 27%, ALT (GPT) decreased by approximately 29%, liver fat content decreased by approximately 22%, and the HOMA-IR index, which measures insulin sensitivity, decreased by approximately 20%.25,26

This single case study may not be universally applied to all patients with reduced body hemostasis. However, this case is reported with the patient's consent because this treatment is believed to have helped improve the patient's symptoms.

  1. Chrousos et al. The concepts of stress and stress system disorders: overview of physical and behavioral homeostasis. JAMA 267.9, 1244-1252 (1992)
    CrossRef
  2. Lee minjong et al. The effects of stress on immune function. Korean Journal of Psychosomatic Medicine, 21(1), 1-6. (2013)
  3. Miller, G. E. et al. Chronic psychological stress and the regulation of pro-inflammatory cytokines: a glucocorticoid-resistance model. Health Psychology, 21(6), 531-541. (2002)
    Pubmed CrossRef
  4. Suarez, E. C. et al. Neuroendocrine, cardiovascular, and emotional responses of hostile men: The role of interpersonal challenge. Psychosomatic Medicine, 60(1), 78-88. (1998)
    Pubmed CrossRef
  5. Rozanski, A. et al. Impact of psychological factors on the pathogenesis of cardiovascular disease and implications for therapy. Circulation, 99(16), 2192-2217. (1999)
    Pubmed CrossRef
  6. Esler, M. Mental stress and human cardiovascular disease. Neuroscience & Biobehavioral Reviews, 74, 269-276. (2017)
    Pubmed CrossRef
  7. Scuteri, A. et al. Arterial aging, hypertension, and arterial stiffness. Hypertension, 51(3), 454-461. (2008)
  8. Hammen, C. Stress and depression. Annual Review of Clinical Psychology, 1, 293-319. (2005)
    Pubmed CrossRef
  9. Pittenger, C. et al. Stress, depression, and neuroplasticity: a convergence of mechanisms. Neuropsychopharmacology, 33, 88-109. (2008)
    Pubmed CrossRef
  10. Kalmbach, D. A. et al. Effects of sleep disturbance on cognition, mood, and health-related quality of life among adults with chronic insomnia: A systematic review. Sleep Medicine Reviews, 18(2014), 195-213. (2014)
    Pubmed CrossRef
  11. Morin, C. M. et al. Role of stress, arousal, and coping skills in primary insomnia. Psychosomatic Medicine, 65, 259-267. (2003)
    Pubmed CrossRef
  12. Liu, P. et al. Comparative study of the effects of Panax notoginseng saponins and Pueraria isoflavones on hypertensive rats. Experimental and Therapeutic Medicine, 14,1713-1719 (2017)
  13. Liang, Y. et al. Effects of Panax notoginseng saponins on cardiovascular diseases: A comprehensive overview of experimental studies. Evidence-Based Complementary and Alternative Medicine, 2019, 4630295 (2019)
  14. Wang, H. et al. Oxygen radical absorbing capacity of anthocyanins. Journal of Agricultural and Food Chemistry, 44(2), 342-346 (1996)
  15. Kim Eunhee, A study on the anthocyanin content of blue tangerines and their immunomodulatory activity. Journal of the Korean Society of Food Science and Nutrition, 46(5), 589-595. (2017).
    CrossRef
  16. Maruyama, H. et al. Anti-inflammatory effect of Fucoidan derived from an edible brown alga, Undaria pinnatifida (Harvey), on IL-8 production in human colorectal carcinoma cells. Journal of Agricultural and Food Chemistry, 51(21), 6240-6244. (2003)
  17. Ferenčík, M. et al. Modulatory effects of selenium and zinc on the immune system. Folia Microbiol 48, 417-426 (2003).
    Pubmed CrossRef
  18. Schrauzer, G. Anticarcinogenic effects of selenium. CMLS, Cell. Mol. Life Sci. 57, 1864-1873 (2000).
    Pubmed CrossRef
  19. Shen Chen et al. Antidepressant Potential of Quercetin and its Glycoside Derivatives: A Comprehensive Review and Update. Front Pharmacol. 13: 865376. (2022)
    Pubmed KoreaMed CrossRef
  20. Serena Silvestro et al. Role of Quercetin in Depressive-Like Behaviors: Findings from Animal Models. Appl. Sci. 11(15), 7116. (2021)
    CrossRef
  21. Laurence S Sperling et al. History and future of omega-3 fatty acids in cardiovascular disease. Curr Med Res Opin. 32(2):301-11. (2016)
    Pubmed CrossRef
  22. Yehuda Handelsman et al. Triglycerides, atherosclerosis, and cardiovascular outcome studies: focus on omega-3 fatty acids. Endocr Pract. 23(1):100-112. (2017)
    Pubmed CrossRef
  23. Gurleen Kaur et al. Omega-3 Fatty Acids for Cardiovascular Event Lowering. Eur J Prev Cardiol . Jan 3: zwae 003. (2024)
  24. Grosso, G. et al. Omega-3 fatty acids and depression: Scientific evidence and biological mechanisms. Oxidative Medicine and Cellular Longevity, 2014, 313570. (2014)
    Pubmed KoreaMed CrossRef
  25. Kawaguchi, T. et al. Hepatoprotective mechanisms of Silymarin: in vitro studies and in vivo efficacy in carbon tetrachloride-induced liver injury in rats. Journal of Clinical Biochemistry and Nutrition, 52, 204-209. (2013)
  26. Adnan Malik et al. Effects of silymarin use on liver enzymes and metabolic factors in metabolic dysfunction-associated steatotic liver disease: a systematic review and meta-analysis. Can Liver J. 26;7(1):40-53 (2024)
    Pubmed KoreaMed CrossRef

Article

Case Report

CellMed 2024; 14(4): 3.1-3.4

Published online March 29, 2024 https://doi.org/10.5667/CellMed.spc.073

Copyright © Cellmed Orthocellular Medicine and Pharmaceutical Association.

세포교정영양요법(OCNT)을 이용한 신체의 항상성 개선 사례 연구

홍은아 약사

부산진구 가야대로 745 홍약국

Received: March 29, 2024; Revised: March 29, 2024; Accepted: March 29, 2024

A Case Study on Improving Body Homeostasis Using Ortho-cellular Nutrition Therapy (OCNT)

Pharmacist, Eunah Hong

Hong Pharmacy, 745, Gaya-daero, Busanjin-gu, Busan, 47258, Republic of Korea

Correspondence to:Eunah Hong
E-mail: eunah0720@naver.com

☨ This report has been translated and edited by the CellMed editor-in-chief, Prof. Beom-Jin Lee.

Received: March 29, 2024; Revised: March 29, 2024; Accepted: March 29, 2024

This is an open access article under the CC BY-NC license. (http://creativecommons.org/licenses/by-nc/3.0/)

Abstract

Objective Case: study on improving body homeostasis by ortho-cellular nutrition therapy.
Methods: A 48-year-old Korean man underwent OCNT due to symptoms of insomnia and decreased physical function due to extreme chronic stress.
Results: After exposure to OCNT, fatigue, sleep quality, and brain fog symptoms improved, and overall physical performance improved, including liver function recovery.
Conclusion: For people who suffer from symptoms of decreased physical function in various aspects due to extreme stress, applying OCNT can help alleviate symptoms.

Keywords: Ortho-Cellular Nutrition Therapy (OCNT), Homeostasis, Stress, Chronic Stress

Introduction

'Stress' is a term in physics, meaning "physical force applied to an object." When applied to medicine, it means "physical and mental stimulation" that burdens an individual or the "reaction" the living body shows when such stimulation is applied.

The human body has a function called homeostasis, which always tries to maintain a certain balance. Homeostasis is a fundamental concept in life phenomena, and one of the critical definitions of disease occurrence is “a breakdown in homeostasis and a decrease in immunity.”

This homeostasis becomes distorted when a robust stressor (a factor that causes stress) is received from the outside or inside. To protect the body from such distortions, restore it, and maintain balance, the body secretes various hormones from the autonomic, nervous, and endocrine systems. In general, it is known that hormones secreted by the autonomic nervous system play an essential role in acute stress, and hormones secreted by the neuroendocrine system play an important role in chronic stress.

When exposed to stress for an extended period, information about stress is transmitted to the hypothalamus through several pathways. Then, the 'corticotropin-releasing factor' is released from the hypothalamus, which stimulates the pituitary gland to secrete adrenocorticotropic hormone. In this case, cortisol, called the 'stress hormone,' is secreted, which increases blood sugar levels and supplies the energy needed to deal with stress. When stress becomes chronic, the secretion of cortisol continues chronically, and if you do not take active measures to maintain homeostasis, the body's balance may be disrupted, and various problems may occur.

The patient, in this case, also suffered from decreased body homeostasis due to excessive chronic stress. As a result, danger signals appeared in various areas, such as insomnia, nosebleeds, arteriosclerosis, obesity, etc. After applying OCTN for a month, fatigue improved, and nosebleeds symptoms were alleviated, but after discontinuation, the same symptoms appeared again, so a second OCTN was performed with additional medication, and we would like to report the progress.

Cases

1. Subject

One case of a patient with decreased body homeostasis due to chronic stress was studied.

1) Name: Kim ㅇㅇ (M/48 years old)

2) Diagnosis: fatty liver, hyperlipidemia (suspected ischemic heart disease and arteriosclerosis), obesity

3) Date of onset: November 2022

4) Treatment period: September 2023 to present

5) Main symptoms: chronic fatigue, chronic insomnia, intermittent headaches, abdominal pain that makes it difficult to fall asleep, jaundice due to fatty liver and hyperlipidemia, severe nosebleeds

6) Past history: Insomnia, depression, panic disorder, nosebleeds around 2012

7) Social history: Smoking (a pack a day), drinking (a can of beer a day)

8) Family history: None

9) Current medical history and medications taken: Sleeping pills and prescription medications for panic disorder (Alprazolam 0.25 mg, 1 Remeron TAB 1 mg, Remixil Oddity 30 mg TAB 1 tablet)

2. Method

A) Oral medication

<August 20023>

Notoplex GRN (101, twice a day, 1 packet each time)

OCNT was carried on for one month as shown above.

<November 20023>

Cyaplex-F CAP (303, twice a day, 3 packets each time)

Eufaplex CAP (303, twice a day, 3 packets each time)

Viva Kan CAP (101, twice a day, 1 packet each time)

Notoplex GRN (100, once a day, 1 packet each time)

OCNT was carried on for one month as shown above.

<Present>

Cyaplex-F CAP (300, twice a day, 3 capsules each time)

Eufaplex CAP (300, twice a day, 3 capsules each time)

Viva Kan CAP (100, once a day, 1 capsule each time)

Diverol CAP (100, once a day, 1 capsule each time)

B) Lifestyle

In lifestyle, it was recommended to refrain from late-night snacking and to always have a positive mind. The patient was advised to abstain from alcohol and smoking but has not been successful in adhering to these recommendations.

Results

The subject of this case is a 48-year-old man who has had insomnia for a long time due to extreme stress from family and work life and has been taking sleeping pills and medication for panic disorder since about ten years ago. He had not been able to take good care of his health for a long time due to mental stress. At the company's health checkup in November 2022, he was diagnosed with ischemic heart disease, peripheral vascular disease such as arteriosclerosis, and adult disease due to high LDL cholesterol levels. He was also diagnosed with moderate fatty liver disease. After a health checkup, he was prescribed the drug atorvastatin, which can reduce cholesterol levels, by the hospital. Still, he did not take it and did not actively manage the suspected disease or obesity.

As fatigue worsened around August 2023, severe nosebleeds became one of the physical symptoms, which led to the start of OCTN. After taking Notoplex for a month, fatigue improved, and nosebleeds stopped, but when the symptoms were partially alleviated, the case subject stopped taking the drug. Then, the same symptoms appeared again in November, so OCTN was performed a second time.

In the second OCTN, four products, Cyaplex-F, Eufaplex, Viva Kan, and Notoplex, were taken according to the prescribed dosage and the patient's health condition improved overall body homeostasis. After a month, fatigue was significantly reduced, sleep quality improved, and the number of times neuropsychiatric medication was taken decreased.

As a result, the brain fog phenomenon was significantly improved compared to before the implementation of OCTN, and awareness became clearer. In addition, by combining OCTN with a diet prohibiting late-night snacking, he lost about 4 kg in one month. His abdominal pain, which was so severe that he could not sleep, was reduced to level 1, and his jaundice levels due to fatty liver and hyperlipidemia were also significantly improved (Table 1).

Table 1 . The degree of symptoms perceived by the patient and measurement values during OCNT.

Symptoms1st 2023.05.302nd 2023.07.053rd 2023.09.25 (After 1st OCTN)4th 2023.12.31 (After 2nd OCTN)Note
Abdominal pain5421The closer the number is to 1, the less pain there is to the point of being unable to sleep.
Weight71.5 kg72 kg69 kg65 kg-
Jaundice14 mg/dL10 mg/dL4 mg/dL2.3 mg/dLNormal range 0.2~1.2 mg/dL


Since the jaundice level is not yet within the normal range, OCNT is still in progress.

Discussion

Stress stimulates the nervous system to secrete the stress hormone cortisol, and when stress becomes chronic, the secretion of cortisol continues chronically, disrupting the body's balance. Suppose you do not promptly take an active response to eliminate stress or an indirect response such as exercise or meditation.

In that case, it becomes difficult for the body to maintain homeostasis, ultimately leading to disease development.1,2 It is known that the nervous system is closely related to the immune system. There are reports that chronic psychological stress increases the level of cortisol and suppresses the activity of immune cells, increasing the risk of developing various infectious diseases or cancer.3

Typical diseases known to be related to stress are introduced as follows:

First, excessive secretion of cortisol promotes fat secretion into the blood, and when this increased fat attaches to the coronary artery wall, it causes coronary artery disease.4,5

Second, if excessive chronic stress continuously stimulates the sympathetic nervous system, leading to an increased risk of hypertension and atherosclerosis.6,7

Third, if stress becomes chronic, this state of activation continues, and if it becomes excessive, it can cause depression. 8,9

Fourth, insomnia occurs when the brain becomes overly tense due to environmental changes or stressors.10,11

Diseases caused by stress not only cause discomfort in daily life but can also directly lead to health issues, making appropriate management crucial. If it's difficult to eliminate the stressor itself, methods to restore the body's homeostasis can also be helpful.

Notoplex, which the patient in this case first took due to excessive nosebleeds, has Panax notoginseng as its main ingredient and is known to be effective in treating blood-related diseases. The main effects include hemostasis to stop bleeding, acid blood to disperse stagnant blood, swelling to clear tumors and swollen wounds, and orthodox to relieve pain. Therefore, taking Panax notoginseng extract can improve the patient's microvascular circulation, assist in vascular relaxation, and help alleviate the patient's nasal congestion symptoms.12,13

Anthocyanins are representative antioxidant substances known to improve immune function through various studies,14,15 and there are reports that fucoidan also enhances immune cells.16 The zinc and selenium contained in the product can also help restore a normal immune system, including detoxification of oxidized cells.17,18

In addition, quercetin contained in aronia is a flavonoid compound with antioxidant and anti-inflammatory effects and increases the expression of brain-derived neurotrophic factors in animal model studies and clinical studies. It has also been shown to improve symptoms of depression by helping to increase levels of neurotransmitters such as serotonin and dopamine.19,20

Omega 3, the main ingredient of Eufaplex, is a non-oxidized essential fatty acid known to help produce prostaglandins 1, 2, and 3, eliminating inflammation and helping kill blood clots and cancer cells. In addition, it is known to help the inflammation control system function normally as it is a parent fatty acid that is a raw material for adrenocortical hormones, cell membrane regeneration, vitamin D synthesis, steroid hormones, and bile. In particular, omega-3 effectively reduces triglyceride and cholesterol levels in many studies.21-23

Omega 3 is also a component of brain cell membranes, plays a vital role in brain cell signaling and neurotransmitter production, and can help improve the function of mood-boosting neurotransmitters such as serotonin and dopamine. It has also been reported that it can help improve symptoms of depression by increasing the expression of BDNF (brain-derived neurotrophic factor) and reducing inflammatory mediators, alleviating cranial nerve inflammation.24

The main ingredient in Viva Kan is silymarin, a mixture of flavonoid compounds extracted from the seeds of a plant called milk thistle. The main components are silybin, silicristine, and silidanin, and research results have reported that it can help improve fatty liver through antioxidant and anti-inflammatory effects. As a result of analyzing 17 randomized controlled studies, when silymarin was consumed, liver enzyme levels, AST (GOT), decreased by approximately 27%, ALT (GPT) decreased by approximately 29%, liver fat content decreased by approximately 22%, and the HOMA-IR index, which measures insulin sensitivity, decreased by approximately 20%.25,26

This single case study may not be universally applied to all patients with reduced body hemostasis. However, this case is reported with the patient's consent because this treatment is believed to have helped improve the patient's symptoms.

Table 1 . The degree of symptoms perceived by the patient and measurement values during OCNT.

Symptoms1st 2023.05.302nd 2023.07.053rd 2023.09.25 (After 1st OCTN)4th 2023.12.31 (After 2nd OCTN)Note
Abdominal pain5421The closer the number is to 1, the less pain there is to the point of being unable to sleep.
Weight71.5 kg72 kg69 kg65 kg-
Jaundice14 mg/dL10 mg/dL4 mg/dL2.3 mg/dLNormal range 0.2~1.2 mg/dL

References

  1. Chrousos et al. The concepts of stress and stress system disorders: overview of physical and behavioral homeostasis. JAMA 267.9, 1244-1252 (1992)
    CrossRef
  2. Lee minjong et al. The effects of stress on immune function. Korean Journal of Psychosomatic Medicine, 21(1), 1-6. (2013)
  3. Miller, G. E. et al. Chronic psychological stress and the regulation of pro-inflammatory cytokines: a glucocorticoid-resistance model. Health Psychology, 21(6), 531-541. (2002)
    Pubmed CrossRef
  4. Suarez, E. C. et al. Neuroendocrine, cardiovascular, and emotional responses of hostile men: The role of interpersonal challenge. Psychosomatic Medicine, 60(1), 78-88. (1998)
    Pubmed CrossRef
  5. Rozanski, A. et al. Impact of psychological factors on the pathogenesis of cardiovascular disease and implications for therapy. Circulation, 99(16), 2192-2217. (1999)
    Pubmed CrossRef
  6. Esler, M. Mental stress and human cardiovascular disease. Neuroscience & Biobehavioral Reviews, 74, 269-276. (2017)
    Pubmed CrossRef
  7. Scuteri, A. et al. Arterial aging, hypertension, and arterial stiffness. Hypertension, 51(3), 454-461. (2008)
  8. Hammen, C. Stress and depression. Annual Review of Clinical Psychology, 1, 293-319. (2005)
    Pubmed CrossRef
  9. Pittenger, C. et al. Stress, depression, and neuroplasticity: a convergence of mechanisms. Neuropsychopharmacology, 33, 88-109. (2008)
    Pubmed CrossRef
  10. Kalmbach, D. A. et al. Effects of sleep disturbance on cognition, mood, and health-related quality of life among adults with chronic insomnia: A systematic review. Sleep Medicine Reviews, 18(2014), 195-213. (2014)
    Pubmed CrossRef
  11. Morin, C. M. et al. Role of stress, arousal, and coping skills in primary insomnia. Psychosomatic Medicine, 65, 259-267. (2003)
    Pubmed CrossRef
  12. Liu, P. et al. Comparative study of the effects of Panax notoginseng saponins and Pueraria isoflavones on hypertensive rats. Experimental and Therapeutic Medicine, 14,1713-1719 (2017)
  13. Liang, Y. et al. Effects of Panax notoginseng saponins on cardiovascular diseases: A comprehensive overview of experimental studies. Evidence-Based Complementary and Alternative Medicine, 2019, 4630295 (2019)
  14. Wang, H. et al. Oxygen radical absorbing capacity of anthocyanins. Journal of Agricultural and Food Chemistry, 44(2), 342-346 (1996)
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CellMed
Apr 30, 2024 Vol.14 No.5, pp. 1.1~5.4

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