Special Article: Case Report

Split Viewer

CellMed 2023; 13(11): 2.1-2.3

Published online August 31, 2023

https://doi.org/10.5667/CellMed.spc.039

© Cellmed Orthocellular Medicine and Pharmaceutical Association

세포교정영양요법(OCNT)을 이용한 류마티스 관절염 개선 사례 연구

최연 약사

광주 서구 운천로 88 운진 빌딩 한샘 약국

A Case Study on the Improvement of Rheumatoid Arthritis Using Ortho Cellular Nutrition Therapy (OCNT)

Pharmacist, Yeon Choi

Hansaem Pharmacy, 88 Unjin Building, Uncheon-ro, Seo-gu, Gwangju, Republic of Korea

Correspondence to : *Yeon choi
E-mail: cy386@hanmail.net

Received: August 24, 2023; Accepted: August 28, 2023

Objective: A case report on the improvement of rheumatoid arthritis using Ortho-Cellular Nutrition Therapy (OCNT)
Methods: A Korean woman in her 50s is suffering from rheumatoid arthritis.
Results: Rheumatoid arthritis improved after performing OCNT.
Conclusion: OCNT can be helpful in the treatment of patients with rheumatoid arthritis.

Keywords Ortho-Cellular Nutrition Therapy (OCNT), Rheumatoid arthritis

Rheumatoid arthritis is a chronic inflammatory disease characterized by progressive damage to synovial joints and various extra-articular symptoms. Symptoms of rheumatoid arthritis include joint swelling and pressure pain in palpation, joint stiffness, and severe motor disorders of the involved joints. Symptoms of rheumatoid arthritis vary, but the most common onset of pain appears with symmetrical swelling of small joints.1 Rheumatoid arthritis exists everywhere in the world with an estimated prevalence of 0.5% to 2%, and the incidence and prevalence are 2-3 times higher in females than in males. The prevalence of rheumatoid arthritis in Korea is estimated at 0.27% to 1.85%, and the male-to-female ratio is 2.7 to 13.5:1.2

The patient, in this case, reported suffering from rheumatoid arthritis, and the patient was admitted to a neuropsychiatric and oriental medicine hospital due to mental and physical stress after being diagnosed with rheumatoid arthritis. After the performance of OCNT, rheumatoid arthritis improved, and this case report is provided with the consent of the patient.

1. Target

It targeted one patient with rheumatoid arthritis.

1)Name: O O O (M/53 years old)

2)Diagnosis: Rheumatoid arthritis, glaucoma

3)Date of Onset: May 2021

4)Treatment Period: Jul. 08, 2021 - current (ongoing)

5)Chief Complaint: Anorexia, weight loss, hot palms, and feet, nausea, vomiting, insomnia

6)Past History: None

7)Social History: No history of smoking and alcohol

8)Family History: None

9)Current medication: Dicamax D

2. Method

The OCNT was initiated in accordance with the following method.

Cyaplex A (101, twice a day, one sachet per dose) Eufaplex Cap. (303, twice a day, 3 capsules per dose) Collaplex (100, once a day, one sachet per dose) Sulfoplex PK Tab. (202, twice a day, 2 tablets per administration)

Selenase (101, twice a day, one tablet per dose)

Aqua SAC Pure (100, once a day, one sachet per dose) Sulfoplex Cream (Apply to the site of pain) Discontinued the prescribed medicine and took only Dicamax D.

After 2 months of taking OCNT:

Blood test results were normal. Solondo was excluded from the prescription.

Dec. 2021

The dose of Sulfoplex PK was increased from 202 to 404 due to worsened pain.

Also, Caroplex (200, once a day, 2 tablets per administration) is added for eye health.

Feb. 2022

Test results were normal. The medical attendant liked the fact that the prescription drug caused no side effects. Returned to work.

Jul. 2022

Viva Circu Cap. (101, twice a day, one tablet per dose) Diverol (100, once a day, one capsule per day)

Added OCNT to improve venous circulation as the patient's job required long-standing hours.

Feb. 2023

The test result revealed that all levels were normal, and Sulfo PK Tab. was reduced to 202 as the pain disappeared.

Apr. 2023

All OCNTs were reduced to once a day as a maintenance dose.

The patient of this case report was suffering from rheumatoid arthritis and was taking Methotrexate, Solondo, Dicamax D, and Celebrex prescribed by the rheumatology department, but there was no improvement in symptoms. Therefore, the patient was admitted to a neuropsychiatric and oriental medicine hospital due to mental and physical stress.

Excessive production of nitric oxide (NO) can cause inflammatory diseases such as rheumatoid arthritis, and anthocyanins in Cyaplex A exhibit the highest inhibitory effect on NO production in a dose-dependent manner.3

Omega-3 found in Eufaplex serves as a precursor to lipid mediators of inflammation attenuates and regulates autoimmune inflammatory responses, and is effective for relieving symptoms of rheumatoid arthritis,4 gamma-linolenic acid (GLA, all cis 6, 9, 12-octade catrienoic acid, C18:3, n6) is produced in the body from linoleic acid (all cis 6, 9-octade cadienoic acid), an essential fatty acid of the omega-6 family, by the delta-6-unsaturated enzyme. It exhibits anti-inflammatory activity by forming DGLA, which can help prevent and treat

inflammatory diseases such as rheumatoid arthritis.5 Shark cartilage powder contained in Collaplex can help relieve symptoms of rheumatoid arthritis by suppressing cellular and humoral immune responses,6 and MSM in Sulfoplex and Sulfoplex Cream is also effective for treating rheumatoid arthritis.7

Selenium in Selenase alleviates rheumatoid arthritis by enhancing the deteriorated antioxidant defense system and reducing increased oxidative stress.8

Lastly, patients with rheumatoid arthritis are supplemented with the calcium contained in Aqua SAC Pure since they have a low calcium/phosphorus ratio. 9 As this is a single case study, the findings may not be universally applicable to all patients with rheumatoid arthritis. However, it is reported with the patient's consent as a case that has shown improvement in symptoms.

  1. Grassi, W., De Angelis, R., Lamanna, G. & Cervini, C. The clinical features of rheumatoid arthritis. European journal of radiology 27 , S18 S24 (1998).
    Pubmed CrossRef
  2. Kim, H. & Sung, Y. K. Epidemiology of rheumatoid arthritis in Korea. Journal of Rheumatic Diseases 28 60 67 (2021).
    Pubmed KoreaMed CrossRef
  3. Li, L. et al. Anthocyanin rich fractions from red raspberries attenuate inflammation in both RAW264. 7 macrophages and a mouse model of colitis. Scientific reports 4 , 6234 (2014).
    Pubmed KoreaMed CrossRef
  4. Kostoglou Athanassiou, I., Athanassiou, L. & Athanassio u, P. The effect of omega 3 fatty acids on rheumatoid arthritis. Mediterranean journal of rheumatology 31 , 190 (2020).
    Pubmed KoreaMed CrossRef
  5. Kapoor, R. & Huang, Y. S. Gamma linolenic acid: an antiinflammatory omega 6 fatty acid. Current pharmaceutical biotechnology 7 , 531 53 4 (2006).
    Pubmed CrossRef
  6. Chen, L., Bao, B., Wang, N., Xie, J. & Wu, W. Oral administration of shark type II collagen suppresses complete Freund’s adjuvant induced rheumatoid arthritis in rats. Pharmaceuticals 5 , 339 352 (2012).
    Pubmed KoreaMed CrossRef
  7. Hasegawa, T., Ueno, S., Kumamoto, S. & Yoshikai, Y. Suppressive effect of methylsulfonylmethane (MSM) on type II collagen induced arthritis in DBA/1J mice. Japanese Pharmacology and Therapeutics 32 , 421 427 (2004).
  8. Qamar, N., John, P. & Bhatti, A. Emerg ing role of selenium in treatment of rheumatoid arthritis: An insight on its antioxidant properties. Journal of Trace Elements in Medicine and Biology 66 , 126737 (2021).
    Pubmed CrossRef
  9. Walwadkar, S., Suryakar, A., Katkam, R., Kumbar, K. & Ankush, R. Oxidative stress a nd calcium phosphorus levels in rheumatoid arthritis. Indian Journal of Clinical Biochemistry 21 , 134 137 (2006).
    Pubmed KoreaMed CrossRef

Article

Case Report

CellMed 2023; 13(11): 2.1-2.3

Published online August 31, 2023 https://doi.org/10.5667/CellMed.spc.039

Copyright © Cellmed Orthocellular Medicine and Pharmaceutical Association.

세포교정영양요법(OCNT)을 이용한 류마티스 관절염 개선 사례 연구

최연 약사

광주 서구 운천로 88 운진 빌딩 한샘 약국

Received: August 24, 2023; Accepted: August 28, 2023

A Case Study on the Improvement of Rheumatoid Arthritis Using Ortho Cellular Nutrition Therapy (OCNT)

Pharmacist, Yeon Choi

Hansaem Pharmacy, 88 Unjin Building, Uncheon-ro, Seo-gu, Gwangju, Republic of Korea

Correspondence to:*Yeon choi
E-mail: cy386@hanmail.net

Received: August 24, 2023; Accepted: August 28, 2023

Abstract

Objective: A case report on the improvement of rheumatoid arthritis using Ortho-Cellular Nutrition Therapy (OCNT)
Methods: A Korean woman in her 50s is suffering from rheumatoid arthritis.
Results: Rheumatoid arthritis improved after performing OCNT.
Conclusion: OCNT can be helpful in the treatment of patients with rheumatoid arthritis.

Keywords: Ortho-Cellular Nutrition Therapy (OCNT), Rheumatoid arthritis

Introduction

Rheumatoid arthritis is a chronic inflammatory disease characterized by progressive damage to synovial joints and various extra-articular symptoms. Symptoms of rheumatoid arthritis include joint swelling and pressure pain in palpation, joint stiffness, and severe motor disorders of the involved joints. Symptoms of rheumatoid arthritis vary, but the most common onset of pain appears with symmetrical swelling of small joints.1 Rheumatoid arthritis exists everywhere in the world with an estimated prevalence of 0.5% to 2%, and the incidence and prevalence are 2-3 times higher in females than in males. The prevalence of rheumatoid arthritis in Korea is estimated at 0.27% to 1.85%, and the male-to-female ratio is 2.7 to 13.5:1.2

The patient, in this case, reported suffering from rheumatoid arthritis, and the patient was admitted to a neuropsychiatric and oriental medicine hospital due to mental and physical stress after being diagnosed with rheumatoid arthritis. After the performance of OCNT, rheumatoid arthritis improved, and this case report is provided with the consent of the patient.

Cases

1. Target

It targeted one patient with rheumatoid arthritis.

1)Name: O O O (M/53 years old)

2)Diagnosis: Rheumatoid arthritis, glaucoma

3)Date of Onset: May 2021

4)Treatment Period: Jul. 08, 2021 - current (ongoing)

5)Chief Complaint: Anorexia, weight loss, hot palms, and feet, nausea, vomiting, insomnia

6)Past History: None

7)Social History: No history of smoking and alcohol

8)Family History: None

9)Current medication: Dicamax D

2. Method

The OCNT was initiated in accordance with the following method.

Cyaplex A (101, twice a day, one sachet per dose) Eufaplex Cap. (303, twice a day, 3 capsules per dose) Collaplex (100, once a day, one sachet per dose) Sulfoplex PK Tab. (202, twice a day, 2 tablets per administration)

Selenase (101, twice a day, one tablet per dose)

Aqua SAC Pure (100, once a day, one sachet per dose) Sulfoplex Cream (Apply to the site of pain) Discontinued the prescribed medicine and took only Dicamax D.

Result

After 2 months of taking OCNT:

Blood test results were normal. Solondo was excluded from the prescription.

Dec. 2021

The dose of Sulfoplex PK was increased from 202 to 404 due to worsened pain.

Also, Caroplex (200, once a day, 2 tablets per administration) is added for eye health.

Feb. 2022

Test results were normal. The medical attendant liked the fact that the prescription drug caused no side effects. Returned to work.

Jul. 2022

Viva Circu Cap. (101, twice a day, one tablet per dose) Diverol (100, once a day, one capsule per day)

Added OCNT to improve venous circulation as the patient's job required long-standing hours.

Feb. 2023

The test result revealed that all levels were normal, and Sulfo PK Tab. was reduced to 202 as the pain disappeared.

Apr. 2023

All OCNTs were reduced to once a day as a maintenance dose.

Consideration

The patient of this case report was suffering from rheumatoid arthritis and was taking Methotrexate, Solondo, Dicamax D, and Celebrex prescribed by the rheumatology department, but there was no improvement in symptoms. Therefore, the patient was admitted to a neuropsychiatric and oriental medicine hospital due to mental and physical stress.

Excessive production of nitric oxide (NO) can cause inflammatory diseases such as rheumatoid arthritis, and anthocyanins in Cyaplex A exhibit the highest inhibitory effect on NO production in a dose-dependent manner.3

Omega-3 found in Eufaplex serves as a precursor to lipid mediators of inflammation attenuates and regulates autoimmune inflammatory responses, and is effective for relieving symptoms of rheumatoid arthritis,4 gamma-linolenic acid (GLA, all cis 6, 9, 12-octade catrienoic acid, C18:3, n6) is produced in the body from linoleic acid (all cis 6, 9-octade cadienoic acid), an essential fatty acid of the omega-6 family, by the delta-6-unsaturated enzyme. It exhibits anti-inflammatory activity by forming DGLA, which can help prevent and treat

inflammatory diseases such as rheumatoid arthritis.5 Shark cartilage powder contained in Collaplex can help relieve symptoms of rheumatoid arthritis by suppressing cellular and humoral immune responses,6 and MSM in Sulfoplex and Sulfoplex Cream is also effective for treating rheumatoid arthritis.7

Selenium in Selenase alleviates rheumatoid arthritis by enhancing the deteriorated antioxidant defense system and reducing increased oxidative stress.8

Lastly, patients with rheumatoid arthritis are supplemented with the calcium contained in Aqua SAC Pure since they have a low calcium/phosphorus ratio. 9 As this is a single case study, the findings may not be universally applicable to all patients with rheumatoid arthritis. However, it is reported with the patient's consent as a case that has shown improvement in symptoms.

References

  1. Grassi, W., De Angelis, R., Lamanna, G. & Cervini, C. The clinical features of rheumatoid arthritis. European journal of radiology 27 , S18 S24 (1998).
    Pubmed CrossRef
  2. Kim, H. & Sung, Y. K. Epidemiology of rheumatoid arthritis in Korea. Journal of Rheumatic Diseases 28 60 67 (2021).
    Pubmed KoreaMed CrossRef
  3. Li, L. et al. Anthocyanin rich fractions from red raspberries attenuate inflammation in both RAW264. 7 macrophages and a mouse model of colitis. Scientific reports 4 , 6234 (2014).
    Pubmed KoreaMed CrossRef
  4. Kostoglou Athanassiou, I., Athanassiou, L. & Athanassio u, P. The effect of omega 3 fatty acids on rheumatoid arthritis. Mediterranean journal of rheumatology 31 , 190 (2020).
    Pubmed KoreaMed CrossRef
  5. Kapoor, R. & Huang, Y. S. Gamma linolenic acid: an antiinflammatory omega 6 fatty acid. Current pharmaceutical biotechnology 7 , 531 53 4 (2006).
    Pubmed CrossRef
  6. Chen, L., Bao, B., Wang, N., Xie, J. & Wu, W. Oral administration of shark type II collagen suppresses complete Freund’s adjuvant induced rheumatoid arthritis in rats. Pharmaceuticals 5 , 339 352 (2012).
    Pubmed KoreaMed CrossRef
  7. Hasegawa, T., Ueno, S., Kumamoto, S. & Yoshikai, Y. Suppressive effect of methylsulfonylmethane (MSM) on type II collagen induced arthritis in DBA/1J mice. Japanese Pharmacology and Therapeutics 32 , 421 427 (2004).
  8. Qamar, N., John, P. & Bhatti, A. Emerg ing role of selenium in treatment of rheumatoid arthritis: An insight on its antioxidant properties. Journal of Trace Elements in Medicine and Biology 66 , 126737 (2021).
    Pubmed CrossRef
  9. Walwadkar, S., Suryakar, A., Katkam, R., Kumbar, K. & Ankush, R. Oxidative stress a nd calcium phosphorus levels in rheumatoid arthritis. Indian Journal of Clinical Biochemistry 21 , 134 137 (2006).
    Pubmed KoreaMed CrossRef
CellMed
Apr 30, 2024 Vol.14 No.5, pp. 1.1~5.4

Stats or Metrics

Share this article on

  • line

CellMed