Case Report

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CellMed 2023; 13(15): 3.1-3.4

Published online November 30, 2023

https://doi.org/10.5667/CellMed.spc.055

© Cellmed Orthocellular Medicine and Pharmaceutical Association

세포교정영양요법(OCNT)을 이용한 SIBO증 환자 개선 사례 연구

민시미 약사

서울 광진구 아차산로 484 치료의 빛 셀메드 약국

A Case Study on the Improvement of a Patient with SIBO Syndrome Using Ortho-Cellular Nutrition Therapy (OCNT)

Pharmacist, Shimi Min

Light of Therapy Cellmed Pharmacy, 4, Achasan-ro, Gwangjin-gu, Seoul, Republic of Korea

Correspondence to : *Shimi Min
E-mail: simimin@hanmail.net

Received: November 29, 2023; Accepted: November 29, 2023

This is an open access article under the CC BY-NC license. (http://creativecommons.org/licenses/by-nc/3.0/)

Objective: To report a case of SIBO syndrome improvement through Ortho-Cellular Nutrition Therapy.
Methods: A Korean male in his 60s suffering from indigestion due to SIBO.
Results: After the OCNT, symptoms of SIBO and indigestion improved.
Conclusion: OCNT can be beneficial for patients with SIBO and indigestion.

Keywords Ortho-Cellular Nutrition Therapy (OCNT), Hypochlorhydria, Indigestion, Small Intestinal Bacterial Overgrowth, SIBO

Small Intestinal Bacterial Overgrowth (SIBO) is defined as an increase in the number or a change in the type of bacteria in the upper gastrointestinal tract. The causes are usually complex and related to insufficient gastric acid secretion, exocrine pancreatic insufficiency, Immunodeficiency syndromes, small bowel obstruction, diverticula, fistulas, etc.1

The patient had hypochlorhydria due to prolonged use of antacids and stress. Long-term use of antacids can decrease gastric acid secretion, resulting in the loss of a physicochemical barrier important for controlling intestinal bacterial growth and settlement, potentially promoting intrinsic infections and increasing the formation of carcinogens in the stomach.2

Reduced gastric acid secretion due to prolonged use of antacids was considered a contributing factor to SIBO. The focus was on reducing bacterial count and normalizing stomach pH.

OCNT was relatively short, but it resulted in an improvement in SIBO, with the patient's consent obtained for case reporting.

1. Subject

A case of a SIBO patient was studied.

1) Name: Mr. Hwang (M/69)

2) Diagnosis: Gastric atony due to SIBO

3) Onset date: After February 2023

4) Treatment period: October 27, 2023, to November 3, 2023

5) Symptoms: Feeling bloated and gassy, a fullness in the stomach

6) Past medical history: None

7) Social history: No alcohol or smoking

8) Family history: None

9) Medications: Antacids, etc.

2. Methods

First OCNT on October 27, 2023:

Enzaplex (111, three times daily, one sachet per time)

Yangwi-bo (111, three times daily, one sachet per time)

These were taken for two days.

Second OCNT on October 30, 2023:

Paragon (101, twice daily, one sachet per time)

Apple vinegar powder (101, twice daily, one sachet per time)

Bioplex (101, twice daily, one sachet per time)

Enzaplex (101, twice daily, one sachet per time)

Taken one sachet each morning and evening for five days.

The patient experienced discomfort in daily life due to a bloated and gassy stomach, feeling full. However, after about one week of OCNT, the bloated feeling and gas improved, indicating an improvement in indigestion.

Hypochlorhydria led to incomplete digestion of food in the stomach, causing intestinal putrefaction and subsequent harmful bacterial growth in the small intestine, resulting in SIBO. Excessive bacteria can interfere with the metabolism and absorption of various substances like carbohydrates, proteins, fats, and vitamins.3

During the first visit, the patient was prescribed Enzaplex and Yangwi-bo three times a day for two days. Enzaplex contains digestive enzymes like protease, amylase, and lipase, which aid in food digestion4, while the tangerine peel in Yangwi-bo improves gastrointestinal motility5, and the toasted rice bran's phenolic compounds and jujubés polysaccharides play an important role in regulating intestinal microorganisms6,7.

Additionally, licorice root 8, and ginger rhizome9 were beneficial for digestion.

After seeing the effects of this two-day regimen, the patient was advised to take Paragon, Apple beanie powder, Bioplex, and Enzaplex again. Paragon's fennel10, buckwheat11, and clove12 aided digestion, and the natural probiotics in Apple beanie powder, the fructooligosaccharide powder in Bioplex13,14, oat fiber15,16, and psyllium husk fiber17 were thought to improve intestinal flora, suppress harmful bacteria, and alleviate the patient's SIBO symptoms, gastric distention and digestive discomfort.

This case report, based on a single case, cannot be universally applied to all patients with digestive issues but is thought to have helped improve the patient's symptoms, hence reported with the patient's consent.

  1. Bures, J. et al. Small intestinal bacterial overgrowth syndrome. World journal of gastroenterology: WJG 16, 2978 (2010).
    Pubmed KoreaMed CrossRef
  2. Selway, S. Potential hazards of long-term acid suppression. Scandinavian Journal of Gastroenterology 25, 85-92 (1990).
    Pubmed CrossRef
  3. Gasbarrini, A. et al. Small Intestinal Bacterial Overgrowth: Diagnosis and Treatment. Digestive Diseases 25, 237-240, (2007).
    Pubmed CrossRef
  4. Ianiro, G., Pecere, S., Giorgio, V., Gasbarrini, A. & Cammarota, G. Digestive Enzyme Supplementation in Gastrointestinal Diseases. Curr Drug Metab 17, 187-193, (2016).
    Pubmed KoreaMed CrossRef
  5. 이현태. 귤나무 과피 유래 한약재 주정 추출물의 위장관 운동 촉진 효과. 생명과학회지 24, 260-265 (2014).
    CrossRef
  6. Sivamaruthi, B. S. et al. Composition, Microbiota, Mechanisms, and Anti-Obesity Properties of Rice Bran. Foods 12, 1300 (2023).
    Pubmed KoreaMed CrossRef
  7. Li, Z. et al. Fingerprinting Evaluation and Gut Microbiota Regulation of Polysaccharides from Jujube (Ziziphus jujuba Mill.) Fruit. International Journal of Molecular Sciences 24, 7239 (2023).
    Pubmed KoreaMed CrossRef
  8. Ding, Y., Brand, E., Wang, W. & Zhao, Z. Licorice: Resources, applications in ancient and modern times. Journal of Ethnopharmacology, 115594 (2022).
    Pubmed CrossRef
  9. Giacosa, A. et al. Can nausea and vomiting be treated with ginger extract? European Review for Medical & Pharmacological Sciences 19 (2015).
  10. Zafar, S., Khan, M. K., Perveen, S., Iqbal, M. & AL-Huqail, A. A. in Essentials of Medicinal and Aromatic Crops 483-514 (Springer, 2023).
    CrossRef
  11. Gang, Z., Yu, T., Anhu, W. & Zhu, H. in Proceeding of the 9th International Symposium on Buckwheat. 630-632.
  12. Milind, P. & Deepa, K. Clove: a champion spice. Int J Res Ayurveda Pharm 2, 47-54 (2011).
  13. Hidaka, H., Eida, T., Takizawa, T., Tokunaga, T. & Tashiro, Y. Effects of fructooligosaccharides on intestinal flora and human health. Bifidobacteria and microflora 5, 37-50 (1986).
    CrossRef
  14. Gibson, G. R. & Roberfroid, M. B. Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. The Journal of nutrition 125, 1401-1412 (1995).
    Pubmed CrossRef
  15. Reddy, B. et al. Biochemical epidemiology of colon cancer: effect of types of dietary fiber on fecal mutagens, acid, and neutral sterols in healthy subjects. Cancer research 49, 4629-4635 (1989).
  16. Zhu, Y. et al. Effects of oat β-glucan, oat resistant starch, and the whole oat flour on insulin resistance, inflammation, and gut microbiota in high-fat-diet-induced type 2 diabetic rats. Journal of Functional Foods 69, 103939 (2020).
    CrossRef
  17. Martellet, M. C., Majolo, F., Ducati, R. G., de Souza, C. F. V. & Goettert, M. I. Probiotic applications associated with Psyllium fiber as prebiotics geared to a healthy intestinal microbiota: A review. Nutrition 103, 111772 (2022).
    Pubmed CrossRef

Article

Case Report

CellMed 2023; 13(15): 3.1-3.4

Published online November 30, 2023 https://doi.org/10.5667/CellMed.spc.055

Copyright © Cellmed Orthocellular Medicine and Pharmaceutical Association.

세포교정영양요법(OCNT)을 이용한 SIBO증 환자 개선 사례 연구

민시미 약사

서울 광진구 아차산로 484 치료의 빛 셀메드 약국

Received: November 29, 2023; Accepted: November 29, 2023

A Case Study on the Improvement of a Patient with SIBO Syndrome Using Ortho-Cellular Nutrition Therapy (OCNT)

Pharmacist, Shimi Min

Light of Therapy Cellmed Pharmacy, 4, Achasan-ro, Gwangjin-gu, Seoul, Republic of Korea

Correspondence to:*Shimi Min
E-mail: simimin@hanmail.net

Received: November 29, 2023; Accepted: November 29, 2023

This is an open access article under the CC BY-NC license. (http://creativecommons.org/licenses/by-nc/3.0/)

Abstract

Objective: To report a case of SIBO syndrome improvement through Ortho-Cellular Nutrition Therapy.
Methods: A Korean male in his 60s suffering from indigestion due to SIBO.
Results: After the OCNT, symptoms of SIBO and indigestion improved.
Conclusion: OCNT can be beneficial for patients with SIBO and indigestion.

Keywords: Ortho-Cellular Nutrition Therapy (OCNT), Hypochlorhydria, Indigestion, Small Intestinal Bacterial Overgrowth, SIBO

INTRODUCTION

Small Intestinal Bacterial Overgrowth (SIBO) is defined as an increase in the number or a change in the type of bacteria in the upper gastrointestinal tract. The causes are usually complex and related to insufficient gastric acid secretion, exocrine pancreatic insufficiency, Immunodeficiency syndromes, small bowel obstruction, diverticula, fistulas, etc.1

The patient had hypochlorhydria due to prolonged use of antacids and stress. Long-term use of antacids can decrease gastric acid secretion, resulting in the loss of a physicochemical barrier important for controlling intestinal bacterial growth and settlement, potentially promoting intrinsic infections and increasing the formation of carcinogens in the stomach.2

Reduced gastric acid secretion due to prolonged use of antacids was considered a contributing factor to SIBO. The focus was on reducing bacterial count and normalizing stomach pH.

OCNT was relatively short, but it resulted in an improvement in SIBO, with the patient's consent obtained for case reporting.

CASE STUDY

1. Subject

A case of a SIBO patient was studied.

1) Name: Mr. Hwang (M/69)

2) Diagnosis: Gastric atony due to SIBO

3) Onset date: After February 2023

4) Treatment period: October 27, 2023, to November 3, 2023

5) Symptoms: Feeling bloated and gassy, a fullness in the stomach

6) Past medical history: None

7) Social history: No alcohol or smoking

8) Family history: None

9) Medications: Antacids, etc.

2. Methods

First OCNT on October 27, 2023:

Enzaplex (111, three times daily, one sachet per time)

Yangwi-bo (111, three times daily, one sachet per time)

These were taken for two days.

Second OCNT on October 30, 2023:

Paragon (101, twice daily, one sachet per time)

Apple vinegar powder (101, twice daily, one sachet per time)

Bioplex (101, twice daily, one sachet per time)

Enzaplex (101, twice daily, one sachet per time)

Taken one sachet each morning and evening for five days.

RESULTS

The patient experienced discomfort in daily life due to a bloated and gassy stomach, feeling full. However, after about one week of OCNT, the bloated feeling and gas improved, indicating an improvement in indigestion.

DISCUSSION

Hypochlorhydria led to incomplete digestion of food in the stomach, causing intestinal putrefaction and subsequent harmful bacterial growth in the small intestine, resulting in SIBO. Excessive bacteria can interfere with the metabolism and absorption of various substances like carbohydrates, proteins, fats, and vitamins.3

During the first visit, the patient was prescribed Enzaplex and Yangwi-bo three times a day for two days. Enzaplex contains digestive enzymes like protease, amylase, and lipase, which aid in food digestion4, while the tangerine peel in Yangwi-bo improves gastrointestinal motility5, and the toasted rice bran's phenolic compounds and jujubés polysaccharides play an important role in regulating intestinal microorganisms6,7.

Additionally, licorice root 8, and ginger rhizome9 were beneficial for digestion.

After seeing the effects of this two-day regimen, the patient was advised to take Paragon, Apple beanie powder, Bioplex, and Enzaplex again. Paragon's fennel10, buckwheat11, and clove12 aided digestion, and the natural probiotics in Apple beanie powder, the fructooligosaccharide powder in Bioplex13,14, oat fiber15,16, and psyllium husk fiber17 were thought to improve intestinal flora, suppress harmful bacteria, and alleviate the patient's SIBO symptoms, gastric distention and digestive discomfort.

This case report, based on a single case, cannot be universally applied to all patients with digestive issues but is thought to have helped improve the patient's symptoms, hence reported with the patient's consent.

References

  1. Bures, J. et al. Small intestinal bacterial overgrowth syndrome. World journal of gastroenterology: WJG 16, 2978 (2010).
    Pubmed KoreaMed CrossRef
  2. Selway, S. Potential hazards of long-term acid suppression. Scandinavian Journal of Gastroenterology 25, 85-92 (1990).
    Pubmed CrossRef
  3. Gasbarrini, A. et al. Small Intestinal Bacterial Overgrowth: Diagnosis and Treatment. Digestive Diseases 25, 237-240, (2007).
    Pubmed CrossRef
  4. Ianiro, G., Pecere, S., Giorgio, V., Gasbarrini, A. & Cammarota, G. Digestive Enzyme Supplementation in Gastrointestinal Diseases. Curr Drug Metab 17, 187-193, (2016).
    Pubmed KoreaMed CrossRef
  5. 이현태. 귤나무 과피 유래 한약재 주정 추출물의 위장관 운동 촉진 효과. 생명과학회지 24, 260-265 (2014).
    CrossRef
  6. Sivamaruthi, B. S. et al. Composition, Microbiota, Mechanisms, and Anti-Obesity Properties of Rice Bran. Foods 12, 1300 (2023).
    Pubmed KoreaMed CrossRef
  7. Li, Z. et al. Fingerprinting Evaluation and Gut Microbiota Regulation of Polysaccharides from Jujube (Ziziphus jujuba Mill.) Fruit. International Journal of Molecular Sciences 24, 7239 (2023).
    Pubmed KoreaMed CrossRef
  8. Ding, Y., Brand, E., Wang, W. & Zhao, Z. Licorice: Resources, applications in ancient and modern times. Journal of Ethnopharmacology, 115594 (2022).
    Pubmed CrossRef
  9. Giacosa, A. et al. Can nausea and vomiting be treated with ginger extract? European Review for Medical & Pharmacological Sciences 19 (2015).
  10. Zafar, S., Khan, M. K., Perveen, S., Iqbal, M. & AL-Huqail, A. A. in Essentials of Medicinal and Aromatic Crops 483-514 (Springer, 2023).
    CrossRef
  11. Gang, Z., Yu, T., Anhu, W. & Zhu, H. in Proceeding of the 9th International Symposium on Buckwheat. 630-632.
  12. Milind, P. & Deepa, K. Clove: a champion spice. Int J Res Ayurveda Pharm 2, 47-54 (2011).
  13. Hidaka, H., Eida, T., Takizawa, T., Tokunaga, T. & Tashiro, Y. Effects of fructooligosaccharides on intestinal flora and human health. Bifidobacteria and microflora 5, 37-50 (1986).
    CrossRef
  14. Gibson, G. R. & Roberfroid, M. B. Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. The Journal of nutrition 125, 1401-1412 (1995).
    Pubmed CrossRef
  15. Reddy, B. et al. Biochemical epidemiology of colon cancer: effect of types of dietary fiber on fecal mutagens, acid, and neutral sterols in healthy subjects. Cancer research 49, 4629-4635 (1989).
  16. Zhu, Y. et al. Effects of oat β-glucan, oat resistant starch, and the whole oat flour on insulin resistance, inflammation, and gut microbiota in high-fat-diet-induced type 2 diabetic rats. Journal of Functional Foods 69, 103939 (2020).
    CrossRef
  17. Martellet, M. C., Majolo, F., Ducati, R. G., de Souza, C. F. V. & Goettert, M. I. Probiotic applications associated with Psyllium fiber as prebiotics geared to a healthy intestinal microbiota: A review. Nutrition 103, 111772 (2022).
    Pubmed CrossRef
CellMed
Feb 29, 2024 Vol.14 No.3, pp. 1.1~4.3

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