Case Report

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CellMed 2024; 14(7): 3.1-3.3

Published online May 31, 2024

https://doi.org/10.5667/CellMed.spc.082

© Cellmed Orthocellular Medicine and Pharmaceutical Association

세포교정영양요법(OCNT)을 이용한 이상지질혈증 및 당뇨 개선 사례 연구

김성희 약사

부산광역시 해운대구 해운대로161번길 43 해맑은약국

A Case Study on the Improvement in Dyslipidemia and Diabetes Patient using Ortho-Cellular Nutrition Therapy (OCNT)

Pharmacist, Sung Hee Kim

Haemalgeun pharmacy, 43, Haeun-daero 161beon-gil, Haeundae-gu, Busan, Republic of Korea

Correspondence to : Sung Hee Kim
E-mail: ilwon6301@hanmail.net

☨ This report has been translated and edited by the CellMed editor-in-chief, Prof. Beom-Jin Lee.

Received: May 30, 2024; Accepted: May 30, 2024

This is an open access article under the CC BY-NC license. (http://creativecommons.org/licenses/by-nc/3.0/)

Objective: Research on improving dyslipidemia and diabetes through Ortho-Cellular Nutrition Therapy (OCNT).
Methods: OCNT was performed on a 77-year-old Korean woman with dyslipidemia and diabetes.
Results: After OCNT, dyslipidemia and diabetes symptoms improved, and the medication could be discontinued or reduced.
Conclusion: Applying OCNT can be helpful for patients suffering from dyslipidemia and diabetes symptoms.

Keywords Ortho-Cellular Nutrition Therapy (OCNT), dyslipidemia, diabetes, drug side effects

Diabetes is a condition in which blood sugar levels are high due to insufficient secretion of insulin or malfunctioning. Diabetes is typically classified into two categories: type 1 diabetes, characterized by difficulty in secreting insulin, and type 2 diabetes, which can secrete insulin but develops relative insulin resistance.1

Type 1 diabetes is known to be caused by the destruction of beta cells that produce insulin due to immune factors. However, in the case of type 2 diabetes, studies have shown that genetic causes like family history, lifestyle habits including obesity or eating habits, and metabolic causes such as gestational diabetes, glucose levels, or insulin resistance play a complex role.2 Additionally, research findings indicates that diabetes can develop as a side effect of steroid use.3

Dyslipidemia refers to high concentrations of low-density lipoprotein (LDL) cholesterol and triglycerides, or low concentrations of high-density lipoprotein (HDL) cholesterol in the plasma. In particular, a survey of dyslipidemia in the Korean population revealed that the prevalence of hypercholesterolemia, a type of dyslipidemia, is gradually increasing. The main causes of this disease are usually a Westernized lifestyle and nutritional intake, and in women, physiological changes such as menopause. In particular, the prevalence rate of dyslipidemia is known to be higher in patients with diabetes or high blood pressure.4

To manage this, various drugs such as statins, resins, fibrates, niacin, and ezetimibe are used as treatments, and statins are the most widely used among these. Statins play a role in lowering LDL cholesterol levels in plasma and are also used to prevent cardiovascular disease. However, there are also have a side effect such as myopathy, rhabdomyolysis, and an increased risk of diabetes.5,6 Therefore, the importance of finding alternative ingredients or medications for statins depending on the patient is gradually increasing.

The patient in this case was suffering from diabetes and dyslipidemia, which were diagnosed during treatment for a chronic disease, but we would like to report a case in which these symptoms were improved through OCNT.

1. Subject

One case of a patient with dyslipidemia and diabetes was studied.

1) Name: Jang OO (F/77 years old)

2) Diagnosis: Dyslipidemia, diabetes

3) Date of onset: April 2022

4) Treatment period: April 2022 - Present

5) Main symptoms: None.

6) Medical history: High blood pressure (diagnosed in February 2019), osteoporosis.

7) Social history: None.

8) Family history: Hypertension, diabetes, hyperlipidemia, gastritis, and lung cancer from younger brother.

9) Medications taken: Norvasc tablets 5mg, Alfocholine tablets, Zemiglo tablets 50mg, Ezet tablets 10mg, Telmican tablets 80mg, Diabex XR tablets 500mg, Cozaar tablets. As of May 2024, Glucophage XR tablets 500mg, Twynsta tablets 80/5mg.

2. Methods

The following OCNT has been applied since April 2022.

1. OCNT

Monacol Capsules (202, twice a day, 2 capsules per dose)

Vivarol capsules (111, three times a day, 1 capsule per dose)

Calmaplex Capsules (202, twice a day, 2 capsules per dose)

Diverol Capsule (010, once a day, 1 capsule per dose)

Three months after the first OCNT, the Monacol capsules were reduced to 101 (twice a day, 1 capsule per dose).

2. Diet

The patient was encouraged to eat more multigrain rice and vegetables and to reduce consumption of white rice, flour, and sugar. Also, combining walking therapy was suggested with the diet.

The progression of the disease and changes in drug prescriptions are shown in Table 1. After starting OCNT, she completely stopped taking Ezet tablets, a hyperlipidemia medication that she had briefly taken initially, based on her doctor's judgment that her dyslipidemia was well managed without it. Additionally, the two types of diabetes medication were reduced to one type. The glycated hemoglobin level for diagnosing diabetes was previously 7.0%, but after OCNT, it was adjusted to 6.6%, which is close to the control target of 6.5% for diabetic patients.

Table 1 . Diagnosis, course, and prescribed medications of case patients over time

Diagnosis and CoursePrescribed Drugs
February 2019Shows symptoms of high blood pressure and mild osteoporosis.Norvasc tablets, Alfocholine tablets
February 2020After receiving steroid injection treatment for hair loss Diagnosed with diabetes.Norvasc tablets, Alfocholine tablets, Diabex XR tablets 500 mg, Zemiglo tablets 50 mg, Livaro tablets*
December 2021Dyslipidemia (hyperlipidemia) was additionally diagnosed.Norvasc tablets, Alfocholine tablets, Ezet tablets 10mg, Coza tablets, Diabex XR sustained-release tablets 500 mg, Zemiglo tablets 50 mg
April 2022OCNT was prescribed.Norvasc tablets, Alfocholine tablets, Ezet tablets 10 mg, Telmican tablets 80 mg, Diabex XR sustained-release tablets 500 mg, Zemiglo tablets 50 mg
July 2022She received an opinion from her doctor that her dyslipidemia was being managed well, but the prescription was maintained.Norvasc tablets, Alfocholine tablets, Ezet tablets 10 mg, Telmican tablets 80 mg, Diabex XR sustained-release tablets 500 mg, Zemiglo tablets 50 mg
CurrentShe received an opinion from her doctor that her dyslipidemia is being managed well. The glycated hemoglobin level also decreased from 7.0 (mmol/mol) to 6.6, and one tablet of hyperlipidemia medication (Ezet Tablet) and one tablet of diabetes medication (Zemiglo Tablet) was reduced.Glucophage XR tablet 500 mg, Twynsta 80/5 mg

* Additional prescriptions received since December 2020.


The case patient was a 77-year-old woman who had suffered from high blood pressure in the past and was taking antihypertensive medication. Afterward, after receiving an injection suspected to be a steroid due to hair loss, diabetes developed as a side effect. At that time, a statin-based drug was prescribed. However, since she had already experienced side effects from steroids, she was advised to discontinue the use of statins due to concerns about potential side effects. After being diagnosed with hyperlipidemia, she took the prescribed ezetimibe medication for the first few days but stopped due to the side effects of heartburn. Therefore, we aimed to manage dyslipidemia while minimizing side effects through OCNT.

Monacolin K, the main ingredient of Monacol, is primarily found in red yeast rice. It is structurally identical to lovastatin and can help reduce blood cholesterol levels. It has also been shown to have effects similar to those of statins but with fewer side effects and better efficacy than simvastatin, one of the drugs used to treat dyslipidemia.7 In addition, alpha-linolenic acid and omega-3 fatty acids, which are abundant in Vivarol, have been shown in numerous studies to significantly lower total cholesterol levels and LDL cholesterol levels.8 In this case, the patient was able to smoothly manage dyslipidemia-related levels through OCNT without taking the prescribed dyslipidemia medication, and was ultimately able to discontinue the medication at the discretion of the attending physician.

In addition, the case patient was taking two types of diabetes-related prescriptions, Zemiglo tablets, and Diabex XR tablets. But after taking Zemiglo, she complained of heartburn and dizziness, so she discontinued the medication after 10 days. Therefore, OCNT was applied to manage diabetes after reducing the medication.

Vitamin D, the main ingredient in Diverol capsules, helps improve diabetes symptoms by lowering insulin resistance and promoting insulin secretion from the beta cells that produce insulin.9 According to a randomized controlled trial, the glycated hemoglobin level and HOMA-IR level, which indicates insulin resistance, were significantly reduced in the patient group taking vitamin D compared to the control group taking placebo.10 Additionally, the calcium contained in Calmaplex regulates insulin responsiveness within cells and helps facilitate smooth insulin action.11 It is believed that these ingredients included in OCNT minimize the side effects experienced by patients, allowing them to smoothly manage diabetes symptoms and reduce glycated hemoglobin levels even when diabetes-related drugs are reduced.

This case is an example of OCNT applied to a single patient, so it is difficult to apply it universally to all dyslipidemia and diabetes patients. However, it is considered significant that the OCNT prescription tailored to the patient minimizes the side effects experienced by the patient, successfully improves dyslipidemia and diabetes symptoms and related values, and makes it possible to reduce the number of medications taken. Therefore, we report this with the patient's consent.

  1. Petersmann A, Müller-Wieland D, Müller UA, et al. Definition, Classification and Diagnosis of Diabetes Mellitus. Exp Clin Endocrinol Diabetes. Dec 2019;127(S 01):S1-s7. doi:10.1055/a-1018-9078
    Pubmed CrossRef
  2. Fletcher B, Gulanick M, Lamendola C. Risk factors for type 2 diabetes mellitus. J Cardiovasc Nurs. Jan 2002;16(2):17-23. doi:10.1097/00005082-200201000-00003
    Pubmed CrossRef
  3. Hwang JL, Weiss RE. Steroid-induced diabetes: a clinical and molecular approach to understanding and treatment. Diabetes Metab Res Rev. Feb 2014;30(2):96-102. doi:10.1002/dmrr.2486
    Pubmed KoreaMed CrossRef
  4. Jin ES, Shim JS, Kim SE, et al. Dyslipidemia Fact Sheet in South Korea, 2022. Diabetes Metab J. Sep 2023;47(5):632-642. doi:10.4093/dmj.2023.0135
    Pubmed KoreaMed CrossRef
  5. Zodda D, Giammona R, Schifilliti S. Treatment Strategy for Dyslipidemia in Cardiovascular Disease Prevention: Focus on Old and New Drugs. Pharmacy (Basel). Jan 21 2018;6(1)doi:10.3390/pharmacy6010010
    Pubmed KoreaMed CrossRef
  6. Laakso M, Fernandes Silva L. Statins and risk of type 2 diabetes: mechanism and clinical implications. Front Endocrinol (Lausanne). 2023;14:1239335. doi:10.3389/fendo.2023.1239335
    Pubmed KoreaMed CrossRef
  7. Liasi E, Kantilafti M, Hadjimbei E, Chrysostomou S. Monacolin K supplementation in patients with hypercholesterolemia: A systematic review of clinical trials. Semergen. May-Jun 2024;50(4):102156. doi:10.1016/j.semerg.2023.102156
    Pubmed CrossRef
  8. Sala-Vila A, Fleming J, Kris-Etherton P, Ros E. Impact of α-Linolenic Acid, the Vegetable ω-3 Fatty Acid, on Cardiovascular Disease and Cognition. Adv Nutr. Oct 2 2022;13(5):1584-1602. doi:10.1093/advances/nmac016
    Pubmed KoreaMed CrossRef
  9. Kayaniyil S, Vieth R, Retnakaran R, et al. Association of vitamin D with insulin resistance and beta-cell dysfunction in subjects at risk for type 2 diabetes. Diabetes Care. Jun 2010;33(6):1379-81. doi:10.2337/dc09-2321
    Pubmed KoreaMed CrossRef
  10. Jehle S, Lardi A, Felix B, Hulter HN, Stettler C, Krapf R. Effect of large doses of parenteral vitamin D on glycaemic control and calcium/phosphate metabolism in patients with stable type 2 diabetes mellitus: a randomised, placebo-controlled, prospective pilot study. Swiss Med Wkly. Mar 20 2014;144:w13942. doi:10.4414/smw.2014.13942
    Pubmed CrossRef
  11. Muñoz-Garach A, García-Fontana B, Muñoz-Torres M. Vitamin D Status, Calcium Intake and Risk of Developing Type 2 Diabetes: An Unresolved Issue. Nutrients. Mar 16 2019;11(3)doi:10.3390/nu11030642
    Pubmed KoreaMed CrossRef

Article

Case Report

CellMed 2024; 14(7): 3.1-3.3

Published online May 31, 2024 https://doi.org/10.5667/CellMed.spc.082

Copyright © Cellmed Orthocellular Medicine and Pharmaceutical Association.

세포교정영양요법(OCNT)을 이용한 이상지질혈증 및 당뇨 개선 사례 연구

김성희 약사

부산광역시 해운대구 해운대로161번길 43 해맑은약국

Received: May 30, 2024; Accepted: May 30, 2024

A Case Study on the Improvement in Dyslipidemia and Diabetes Patient using Ortho-Cellular Nutrition Therapy (OCNT)

Pharmacist, Sung Hee Kim

Haemalgeun pharmacy, 43, Haeun-daero 161beon-gil, Haeundae-gu, Busan, Republic of Korea

Correspondence to:Sung Hee Kim
E-mail: ilwon6301@hanmail.net

☨ This report has been translated and edited by the CellMed editor-in-chief, Prof. Beom-Jin Lee.

Received: May 30, 2024; Accepted: May 30, 2024

This is an open access article under the CC BY-NC license. (http://creativecommons.org/licenses/by-nc/3.0/)

Abstract

Objective: Research on improving dyslipidemia and diabetes through Ortho-Cellular Nutrition Therapy (OCNT).
Methods: OCNT was performed on a 77-year-old Korean woman with dyslipidemia and diabetes.
Results: After OCNT, dyslipidemia and diabetes symptoms improved, and the medication could be discontinued or reduced.
Conclusion: Applying OCNT can be helpful for patients suffering from dyslipidemia and diabetes symptoms.

Keywords: Ortho-Cellular Nutrition Therapy (OCNT), dyslipidemia, diabetes, drug side effects

INTRODUCTION

Diabetes is a condition in which blood sugar levels are high due to insufficient secretion of insulin or malfunctioning. Diabetes is typically classified into two categories: type 1 diabetes, characterized by difficulty in secreting insulin, and type 2 diabetes, which can secrete insulin but develops relative insulin resistance.1

Type 1 diabetes is known to be caused by the destruction of beta cells that produce insulin due to immune factors. However, in the case of type 2 diabetes, studies have shown that genetic causes like family history, lifestyle habits including obesity or eating habits, and metabolic causes such as gestational diabetes, glucose levels, or insulin resistance play a complex role.2 Additionally, research findings indicates that diabetes can develop as a side effect of steroid use.3

Dyslipidemia refers to high concentrations of low-density lipoprotein (LDL) cholesterol and triglycerides, or low concentrations of high-density lipoprotein (HDL) cholesterol in the plasma. In particular, a survey of dyslipidemia in the Korean population revealed that the prevalence of hypercholesterolemia, a type of dyslipidemia, is gradually increasing. The main causes of this disease are usually a Westernized lifestyle and nutritional intake, and in women, physiological changes such as menopause. In particular, the prevalence rate of dyslipidemia is known to be higher in patients with diabetes or high blood pressure.4

To manage this, various drugs such as statins, resins, fibrates, niacin, and ezetimibe are used as treatments, and statins are the most widely used among these. Statins play a role in lowering LDL cholesterol levels in plasma and are also used to prevent cardiovascular disease. However, there are also have a side effect such as myopathy, rhabdomyolysis, and an increased risk of diabetes.5,6 Therefore, the importance of finding alternative ingredients or medications for statins depending on the patient is gradually increasing.

The patient in this case was suffering from diabetes and dyslipidemia, which were diagnosed during treatment for a chronic disease, but we would like to report a case in which these symptoms were improved through OCNT.

CASE REPORT

1. Subject

One case of a patient with dyslipidemia and diabetes was studied.

1) Name: Jang OO (F/77 years old)

2) Diagnosis: Dyslipidemia, diabetes

3) Date of onset: April 2022

4) Treatment period: April 2022 - Present

5) Main symptoms: None.

6) Medical history: High blood pressure (diagnosed in February 2019), osteoporosis.

7) Social history: None.

8) Family history: Hypertension, diabetes, hyperlipidemia, gastritis, and lung cancer from younger brother.

9) Medications taken: Norvasc tablets 5mg, Alfocholine tablets, Zemiglo tablets 50mg, Ezet tablets 10mg, Telmican tablets 80mg, Diabex XR tablets 500mg, Cozaar tablets. As of May 2024, Glucophage XR tablets 500mg, Twynsta tablets 80/5mg.

2. Methods

The following OCNT has been applied since April 2022.

1. OCNT

Monacol Capsules (202, twice a day, 2 capsules per dose)

Vivarol capsules (111, three times a day, 1 capsule per dose)

Calmaplex Capsules (202, twice a day, 2 capsules per dose)

Diverol Capsule (010, once a day, 1 capsule per dose)

Three months after the first OCNT, the Monacol capsules were reduced to 101 (twice a day, 1 capsule per dose).

2. Diet

The patient was encouraged to eat more multigrain rice and vegetables and to reduce consumption of white rice, flour, and sugar. Also, combining walking therapy was suggested with the diet.

RESULTS

The progression of the disease and changes in drug prescriptions are shown in Table 1. After starting OCNT, she completely stopped taking Ezet tablets, a hyperlipidemia medication that she had briefly taken initially, based on her doctor's judgment that her dyslipidemia was well managed without it. Additionally, the two types of diabetes medication were reduced to one type. The glycated hemoglobin level for diagnosing diabetes was previously 7.0%, but after OCNT, it was adjusted to 6.6%, which is close to the control target of 6.5% for diabetic patients.

Table 1 . Diagnosis, course, and prescribed medications of case patients over time.

Diagnosis and CoursePrescribed Drugs
February 2019Shows symptoms of high blood pressure and mild osteoporosis.Norvasc tablets, Alfocholine tablets
February 2020After receiving steroid injection treatment for hair loss Diagnosed with diabetes.Norvasc tablets, Alfocholine tablets, Diabex XR tablets 500 mg, Zemiglo tablets 50 mg, Livaro tablets*
December 2021Dyslipidemia (hyperlipidemia) was additionally diagnosed.Norvasc tablets, Alfocholine tablets, Ezet tablets 10mg, Coza tablets, Diabex XR sustained-release tablets 500 mg, Zemiglo tablets 50 mg
April 2022OCNT was prescribed.Norvasc tablets, Alfocholine tablets, Ezet tablets 10 mg, Telmican tablets 80 mg, Diabex XR sustained-release tablets 500 mg, Zemiglo tablets 50 mg
July 2022She received an opinion from her doctor that her dyslipidemia was being managed well, but the prescription was maintained.Norvasc tablets, Alfocholine tablets, Ezet tablets 10 mg, Telmican tablets 80 mg, Diabex XR sustained-release tablets 500 mg, Zemiglo tablets 50 mg
CurrentShe received an opinion from her doctor that her dyslipidemia is being managed well. The glycated hemoglobin level also decreased from 7.0 (mmol/mol) to 6.6, and one tablet of hyperlipidemia medication (Ezet Tablet) and one tablet of diabetes medication (Zemiglo Tablet) was reduced.Glucophage XR tablet 500 mg, Twynsta 80/5 mg

* Additional prescriptions received since December 2020..


DISCUSSION

The case patient was a 77-year-old woman who had suffered from high blood pressure in the past and was taking antihypertensive medication. Afterward, after receiving an injection suspected to be a steroid due to hair loss, diabetes developed as a side effect. At that time, a statin-based drug was prescribed. However, since she had already experienced side effects from steroids, she was advised to discontinue the use of statins due to concerns about potential side effects. After being diagnosed with hyperlipidemia, she took the prescribed ezetimibe medication for the first few days but stopped due to the side effects of heartburn. Therefore, we aimed to manage dyslipidemia while minimizing side effects through OCNT.

Monacolin K, the main ingredient of Monacol, is primarily found in red yeast rice. It is structurally identical to lovastatin and can help reduce blood cholesterol levels. It has also been shown to have effects similar to those of statins but with fewer side effects and better efficacy than simvastatin, one of the drugs used to treat dyslipidemia.7 In addition, alpha-linolenic acid and omega-3 fatty acids, which are abundant in Vivarol, have been shown in numerous studies to significantly lower total cholesterol levels and LDL cholesterol levels.8 In this case, the patient was able to smoothly manage dyslipidemia-related levels through OCNT without taking the prescribed dyslipidemia medication, and was ultimately able to discontinue the medication at the discretion of the attending physician.

In addition, the case patient was taking two types of diabetes-related prescriptions, Zemiglo tablets, and Diabex XR tablets. But after taking Zemiglo, she complained of heartburn and dizziness, so she discontinued the medication after 10 days. Therefore, OCNT was applied to manage diabetes after reducing the medication.

Vitamin D, the main ingredient in Diverol capsules, helps improve diabetes symptoms by lowering insulin resistance and promoting insulin secretion from the beta cells that produce insulin.9 According to a randomized controlled trial, the glycated hemoglobin level and HOMA-IR level, which indicates insulin resistance, were significantly reduced in the patient group taking vitamin D compared to the control group taking placebo.10 Additionally, the calcium contained in Calmaplex regulates insulin responsiveness within cells and helps facilitate smooth insulin action.11 It is believed that these ingredients included in OCNT minimize the side effects experienced by patients, allowing them to smoothly manage diabetes symptoms and reduce glycated hemoglobin levels even when diabetes-related drugs are reduced.

This case is an example of OCNT applied to a single patient, so it is difficult to apply it universally to all dyslipidemia and diabetes patients. However, it is considered significant that the OCNT prescription tailored to the patient minimizes the side effects experienced by the patient, successfully improves dyslipidemia and diabetes symptoms and related values, and makes it possible to reduce the number of medications taken. Therefore, we report this with the patient's consent.

Table 1 . Diagnosis, course, and prescribed medications of case patients over time.

Diagnosis and CoursePrescribed Drugs
February 2019Shows symptoms of high blood pressure and mild osteoporosis.Norvasc tablets, Alfocholine tablets
February 2020After receiving steroid injection treatment for hair loss Diagnosed with diabetes.Norvasc tablets, Alfocholine tablets, Diabex XR tablets 500 mg, Zemiglo tablets 50 mg, Livaro tablets*
December 2021Dyslipidemia (hyperlipidemia) was additionally diagnosed.Norvasc tablets, Alfocholine tablets, Ezet tablets 10mg, Coza tablets, Diabex XR sustained-release tablets 500 mg, Zemiglo tablets 50 mg
April 2022OCNT was prescribed.Norvasc tablets, Alfocholine tablets, Ezet tablets 10 mg, Telmican tablets 80 mg, Diabex XR sustained-release tablets 500 mg, Zemiglo tablets 50 mg
July 2022She received an opinion from her doctor that her dyslipidemia was being managed well, but the prescription was maintained.Norvasc tablets, Alfocholine tablets, Ezet tablets 10 mg, Telmican tablets 80 mg, Diabex XR sustained-release tablets 500 mg, Zemiglo tablets 50 mg
CurrentShe received an opinion from her doctor that her dyslipidemia is being managed well. The glycated hemoglobin level also decreased from 7.0 (mmol/mol) to 6.6, and one tablet of hyperlipidemia medication (Ezet Tablet) and one tablet of diabetes medication (Zemiglo Tablet) was reduced.Glucophage XR tablet 500 mg, Twynsta 80/5 mg

* Additional prescriptions received since December 2020..


References

  1. Petersmann A, Müller-Wieland D, Müller UA, et al. Definition, Classification and Diagnosis of Diabetes Mellitus. Exp Clin Endocrinol Diabetes. Dec 2019;127(S 01):S1-s7. doi:10.1055/a-1018-9078
    Pubmed CrossRef
  2. Fletcher B, Gulanick M, Lamendola C. Risk factors for type 2 diabetes mellitus. J Cardiovasc Nurs. Jan 2002;16(2):17-23. doi:10.1097/00005082-200201000-00003
    Pubmed CrossRef
  3. Hwang JL, Weiss RE. Steroid-induced diabetes: a clinical and molecular approach to understanding and treatment. Diabetes Metab Res Rev. Feb 2014;30(2):96-102. doi:10.1002/dmrr.2486
    Pubmed KoreaMed CrossRef
  4. Jin ES, Shim JS, Kim SE, et al. Dyslipidemia Fact Sheet in South Korea, 2022. Diabetes Metab J. Sep 2023;47(5):632-642. doi:10.4093/dmj.2023.0135
    Pubmed KoreaMed CrossRef
  5. Zodda D, Giammona R, Schifilliti S. Treatment Strategy for Dyslipidemia in Cardiovascular Disease Prevention: Focus on Old and New Drugs. Pharmacy (Basel). Jan 21 2018;6(1)doi:10.3390/pharmacy6010010
    Pubmed KoreaMed CrossRef
  6. Laakso M, Fernandes Silva L. Statins and risk of type 2 diabetes: mechanism and clinical implications. Front Endocrinol (Lausanne). 2023;14:1239335. doi:10.3389/fendo.2023.1239335
    Pubmed KoreaMed CrossRef
  7. Liasi E, Kantilafti M, Hadjimbei E, Chrysostomou S. Monacolin K supplementation in patients with hypercholesterolemia: A systematic review of clinical trials. Semergen. May-Jun 2024;50(4):102156. doi:10.1016/j.semerg.2023.102156
    Pubmed CrossRef
  8. Sala-Vila A, Fleming J, Kris-Etherton P, Ros E. Impact of α-Linolenic Acid, the Vegetable ω-3 Fatty Acid, on Cardiovascular Disease and Cognition. Adv Nutr. Oct 2 2022;13(5):1584-1602. doi:10.1093/advances/nmac016
    Pubmed KoreaMed CrossRef
  9. Kayaniyil S, Vieth R, Retnakaran R, et al. Association of vitamin D with insulin resistance and beta-cell dysfunction in subjects at risk for type 2 diabetes. Diabetes Care. Jun 2010;33(6):1379-81. doi:10.2337/dc09-2321
    Pubmed KoreaMed CrossRef
  10. Jehle S, Lardi A, Felix B, Hulter HN, Stettler C, Krapf R. Effect of large doses of parenteral vitamin D on glycaemic control and calcium/phosphate metabolism in patients with stable type 2 diabetes mellitus: a randomised, placebo-controlled, prospective pilot study. Swiss Med Wkly. Mar 20 2014;144:w13942. doi:10.4414/smw.2014.13942
    Pubmed CrossRef
  11. Muñoz-Garach A, García-Fontana B, Muñoz-Torres M. Vitamin D Status, Calcium Intake and Risk of Developing Type 2 Diabetes: An Unresolved Issue. Nutrients. Mar 16 2019;11(3)doi:10.3390/nu11030642
    Pubmed KoreaMed CrossRef
CellMed
Jun 30, 2024 Vol.14 No.8, pp. 1.1~4.4

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